Microphthalmia Associated Transcription Factor (MITF)
Microphthalmia Associated Transcription Factor
Microphthalmia Associated Transcription Factor (MITF) is a transcription factor that plays a key role in cell differentiation, development and maintenance of physiological functions. It belongs to the MiT (microphthalmia transcription factor) basic helix-loop-helix family. Microphthalmia Associated Transcription Factor (MITF) has at least MITF-A, MITF-B, MITF-C, MITF-H and MITF-M subtypes, each of which has a different structure due to its unique N-terminal coding exon. MITF has many interacting targets, such as β-catenin, which can change β-catenin transcriptional activity and thus affect gene expression; GLI2, TGF-β, etc., which affect cell processes by inhibiting MITF transcription.
In addition, miR-204/211 is also an important target regulated by MITF and participates in the process of cell differentiation. MITF is essential for the development, maintenance and differentiation of melanocytes, regulating the transcription of melanin production enzyme genes; in retinal pigment epithelial cells, it promotes cell differentiation by regulating miR-204/211 expression. MITF is associated with a variety of diseases, and its p.E318K mutation is associated with an increased risk of melanoma and renal cell carcinoma. In renal cell carcinoma, patients carrying this mutation often present with bilateral multifocal type 1 papillary renal cell carcinoma; MITF gene abnormalities are also associated with Waardenburg syndrome, Tietz syndrome and other auditory-pigmentary diseases[1][2][3][4][5][6][7][8][9].
All Product Categories
-
Microphthalmia Associated Transcription Factor (MITF) Related Products (6)
-
ML329
0 ImagesML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM.
-
TT-012
0 ImagesTT-012 is a MITF inhibitor with a human MITF IC50 of 13.1 nM and a human MITF Kd value of 15.5 nM. TT-012 reduces mRNA levels of MITF downstream genes linked to melanosome biogenesis, cell survival, and proliferation, and upregulates cell cycle-inhibiting genes. TT-012 can be used for the research of melanoma[1][2][3].
-
Tribuloside
0 ImagesTribuloside is a flavonoid and PDE4 inhibitor (IC50: 6 μM). Tribuloside exhibits antibacterial and antioxidant activities, capable of scavenging DPPH free radicals. Tribuloside also promotes melanogenesis. Tribuloside can be used in the research of hypopigmentary diseases, sun protection, and inflammatory diseases such as acute lung injury.
-
WZS0347
0 ImagesCat. No.: HY-179717Purity: 99.06%WZS0347 is a MITF PROTAC degrader. WZS0347 effectively reduces the MITF protein levels in several melanoma cell lines, including B16F10, A375, and GAK. WZS0347 significantly inhibits the proliferation, migration, and invasion of melanoma cells. WZS0347 can be used for research on melanoma.
-
10(E)-Pentadecenoic acid
0 ImagesSynonyms: trans-10-Pentadecenoic acid10 (E)-Pentadecenoic acid (trans-10-Pentadecenoic acid) is a melanin synthesis inhibitor. 10 (E)-Pentadecenoic acid inhibits nuclear translocation and reduces the protein level of phosphorylated microphthalmia-associated transcription factor (MITF), as well as decreases intracellular tyrosinase activity. 10 (E)-Pentadecenoic acid can be used in the research of skin pigmentation disorders.
